Top 14 Sandwiches restaurants in Little Italy
Little Italy is known for its vibrant culture and delicious food. Among the various dining options, sandwiches restaurants in Little Italy stand out as a must-visit. These establishments offer a wide range of creative and flavorful sandwiches, using fresh, locally-sourced ingredients. Whether you're in the mood for a classic Italian sub or something more adventurous, sandwiches restaurants in Little Italy have got you covered. Experience the unique culinary scene and indulge in a delicious sandwich at one of these notable spots in Little Italy.
- 1. Mona Lisa Italian Foods
- 2. Filippi's Pizza Grotto Little Italy
- 3. Sicilian-ish Cafe and Deli
- 4. Little Italy Food Hall in Little Italy
- 5. Petrini's San Diego in Little Italy
- 6. Barbusa
- 7. Puerto La Boca
- 8. Davanti Enoteca
- 9. Monello
- 10. Herb & Wood
- 11. Bencotto
- 12. RoVino Restaurant + Bar
- 13. Roman Wolves
- 14. Ambrogio15 Little Italy in Little Italy
1. Mona Lisa Italian Foods
Family-owned business since 1976, Freshly baked bread daily, Uses high-quality ingredients

The deli of Mona Lisa is renowned for its exceptional sandwiches, with the Deluxe Sub and Spicy Sandwich Special being among the top choices. The high-quality meats, ingredients, and bread are what make these subs stand out in San Diego. This deli has been a consistent favorite for 15 years, with a loyal customer base that appreciates the family-run business and the friendly service.
This establishment is famous for its authentic Italian sub-style sandwiches, which are highly regarded not only in San Diego but potentially anywhere. The consistency in quality and service over the years has made it a beloved and reliable spot for locals and visitors alike. The deli's dedication to providing excellent sandwiches and customer experience has earned it a special place in the San Diego community.
TOPICS
- Italian Cuisine
- Mid-Range
- Downtown Spots
- Dinner
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2. Filippi's Pizza Grotto Little Italy
Underground wine cellar and Italian imports store

We enjoyed pizza during our meal, but other dishes such as sandwiches and lasagna also caught our attention and looked appealing. Among the sandwiches, the meatball variant stood out as a particularly delicious and satisfying option.
It's worth noting that the meatball sandwich was not only delicious but also very filling. This suggests that the sandwich contained a generous amount of high-quality ingredients, making it a substantial and satisfying choice for anyone looking for a hearty meal. The combination of flavors and textures in the meatball sandwich was sure to please even the most discerning of palates.
TOPICS
- Italian Cuisine
- Downtown Spots
- Dinner
- Mid-Range
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3. Sicilian-ish Cafe and Deli

TOPICS
- Italian Cuisine
- Budget-Friendly Eats
- Downtown Spots
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4. Little Italy Food Hall in Little Italy
Offers catering services, Has a daily specials board

The roast beef sandwich at the food hall is a standout, packed with delicious flavor that makes it a must-try for any visitor. This sandwich is just one example of the high-quality options available at the food hall, where every dish is carefully crafted with fresh, tasty ingredients.
In addition to the roast beef sandwich, the turkey club is another excellent choice for those looking to sample the menu. This sandwich features top-notch turkey, along with crispy bacon, fresh lettuce, and ripe tomatoes, all served on soft, toasted bread. Whether you choose the roast beef or the turkey club, you're in for a treat at this food hall.
TOPICS
- Fusion Cuisine
- Downtown Spots
- Mid-Range
- Dinner
5. Petrini's San Diego in Little Italy
Housemade porchetta, Freshly baked bread, Local ingredients

The classic meatball hoagie is a popular sandwich choice. Fresh bread is used for the hoagie, giving it a great taste and texture. The meatballs themselves are juicy and well-seasoned, adding to the overall flavor of the sandwich.
The meatball hoagie is a delicious and flavorful sandwich. Its juicy meatballs and fresh bread make it a must-try for anyone who enjoys a good sandwich. The combination of these ingredients results in a satisfying and enjoyable eating experience.
TOPICS
- Italian Cuisine
- Downtown Spots
- Dinner
- Mid-Range
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6. Barbusa
Mediterranean-inspired sandwiches with vegetarian and vegan options

The location is appealing for a rapid and satisfying meal. The sandwiches are a standout item on the menu, highly recommended for their delicious taste and fresh ingredients. The staff is known for their amiable and helpful attitude, contributing to a welcoming and pleasant dining experience.
The quality of the food served is excellent, with the sandwiches being a particular highlight. They are generously filled with premium ingredients, resulting in a delightful and tasty meal. The atmosphere of the establishment is animated, providing a vibrant and enjoyable ambiance. Moreover, the service is commendable, with staff demonstrating a high level of professionalism and attentiveness to customers' needs.
TOPICS
- Mediterranean Cuisine
- Downtown Spots
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7. Puerto La Boca
Authentic Argentine cuisine in the heart of San Diego

The Lomito sandwich at Puerto La Boca is a standout option, offering an explosion of flavor and a satisfying portion size. The Choripan sandwich is another excellent choice, boasting a rich taste that is enhanced by the accompanying chimichurri sauce.
Puerto La Boca is a restaurant that is highly recommended for sandwich lovers. The Lomito sandwich is one of the best I have ever had, with a perfect balance of flavors and a generous portion. The Choripan sandwich is also worth trying, as it features a delicious combination of flavors and a unique twist with the chimichurri sauce.
TOPICS
- Mediterranean Cuisine
- Italian Cuisine
- Dinner
- Downtown Spots
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8. Davanti Enoteca
Cozy and charming Italian wine bar atmosphere

The sandwiches at this establishment are truly exceptional. One standout option is the prosciutto and mozzarella sandwich, which boasts fresh bread and high-quality ingredients. Another impressive selection is the truffle egg toast sandwich - the flavors are skillfully balanced, and the portion size is satisfying.
Visitors to this eatery are sure to enjoy the sandwich offerings. The prosciutto and mozzarella sandwich is a must-try, with its excellent bread and top-tier ingredients. For those seeking something a bit different, the truffle egg toast sandwich is a fantastic choice, offering a delightful balance of flavors and a portion size that is both filling and reasonable.
TOPICS
- Italian Cuisine
- Vegetarian Options
- Vegan Options
- Kosher Options
9. Monello
Known for their locally sourced meats and artisanal breads.

The sandwiches at this establishment are truly exceptional. The panini, in particular, stands out with its perfectly toasted bread and fresh, flavorful fillings. The sandwich's quality remained intact even when ordered for delivery, still arriving warm and tasty.
I would highly recommend the prosciutto sandwich. Every component, from the bread to the filling, worked in harmony to create a truly delightful eating experience. The freshness of the ingredients used was evident, and the sandwich's preparation was carried out with great care. Overall, it was a top-notch sandwich that left a lasting impression.
TOPICS
- Italian Cuisine
- Downtown Spots
- Corporate Events
- Vegetarian Options
10. Herb & Wood
Wood-fired sandwiches, local sourcing, seasonal ingredients

Herb & Wood is known for serving delicious sandwiches. The bread used in their sandwiches is always fresh, and the fillings are well-balanced with flavorful ingredients. Among the offerings, the chicken sandwich stands out for its exceptional taste. The chicken used in the sandwich is fresh, and the combination of ingredients results in a delightful flavor explosion.
Visitors to Herb & Wood cannot go wrong with ordering one of their sandwiches. The chicken sandwich, in particular, is a must-try, boasting fresh chicken and a medley of flavors that will not disappoint. The high-quality ingredients and thoughtful preparation make for a sandwich that is sure to satisfy.
TOPICS
- Fusion Cuisine
- Asian Cuisine
- Mediterranean Cuisine
- Downtown Spots
11. Bencotto
Authentic Italian sandwiches, Casual atmosphere

The food served at the restaurant was delicious and satisfying. The staff provided excellent service, ensuring that the food was served in a timely manner. They were also attentive to the customers' needs, providing warm outdoor heaters for those who chose to dine outside. The overall experience was highly enjoyable, and the reviewer would definitely consider visiting again.
The restaurant is known for its excellent pasta dishes. However, customers should be prepared for a long wait, even with a reservation. The food is worth waiting for, as it is of the highest quality and offers an authentic Italian flavor. The restaurant's reputation for amazing Italian cuisine is well-deserved, and the wait is a small price to pay for the delightful dishes that await. It is recommended to be patient and enjoy the atmosphere while waiting for the meal to arrive.
TOPICS
- Social Gatherings
- Italian Cuisine
- Downtown Spots
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12. RoVino Restaurant + Bar
Features an extensive wine list and a dog-friendly patio

This place is a great destination for sandwiches, with two standout options being the prosciutto and Italian varieties. The bread in each sandwich is fresh, and the fillings are packed with flavor. The service at this establishment has also been noted for its excellence, contributing to an overall positive dining experience.
If you're in the mood for a sandwich, this place is a must-visit. In particular, the prosciutto sandwich is a crowd favorite, while the Italian sandwich is also highly recommended. The bread and fillings are both top-notch, making for a delicious meal. On top of that, the service is known to be excellent, ensuring a pleasant dining experience.
TOPICS
- Italian Cuisine
- Downtown Spots
- Dinner
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13. Roman Wolves
This sandwich shop is located in the heart of downtown San Diego, offers catering services, and has a cozy atmosphere.

The service at the restaurant was subpar, with long wait times and inconsistent attention from the waitstaff. After ordering drinks, it took over an hour and a half for the main course to arrive, despite other tables receiving their desserts and preparing to leave. The waiter gave inconsistent updates on the status of the food, leaving the diners uncertain and still waiting. Eventually, the pasta was boxed up and taken home. The waiter seemed to prioritize a table of six girls celebrating a birthday, neglecting other patrons.
Despite the poor service, the food at Roman Wolves was satisfactory. The menu features delicious pasta dishes, including the Great Carbonara, and an impressive cheese wheel show. The atmosphere is modern and clean, with attentive and kind servers like Gianluca and Vincenzo providing great service and recommendations. Overall, Roman Wolves earns a 10/10 recommendation from satisfied customers for its excellent service and ambiance. However, the service experience described may not be representative of what all customers can expect.
TOPICS
- Mediterranean Cuisine
- Vegan Options
- High-End
- Downtown Spots
14. Ambrogio15 Little Italy in Little Italy
Family-owned restaurant with a strong focus on tradition

If you're seeking a delicious Italian sandwich, Ambrogio15 in Little Italy is the place to visit. The Italian sandwich offered is packed with flavor, thanks to generously filled ingredients and perfectly toasted bread. This establishment is highly recommended for a satisfying meal.
The bread at Ambrogio15 is toasted to perfection, providing a satisfying crunch with each bite. The sandwich's fillings are generous and bursting with flavor, making for a truly enjoyable dining experience. Whether you're a fan of Italian cuisine or just looking for a great sandwich, Ambrogio15 is the perfect spot.
TOPICS
- Italian Cuisine
- Downtown Spots
- Dinner
- Mid-Range
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